The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments.
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The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
The proprotein convertase PC5 is encoded by multiple mRNAs, two of which give rise to the COOH-terminal variant isoforms PC5-A (915 amino acids [aa]) and PC5-B (1877 aa). To investigate the differences in biosynthesis and sorting between these two proteins, we generated stably transfected AtT-20 cell lines expressing each enzyme individually and examined their respective processing pattern and ...
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Thilo HAGEN*1, Jaswinder K. SETHI†, Neale FOXWELL‡ and Antonio VIDAL-PUIG† *Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, U.K., †Department of Clinical Biochemistry, University of Cambridge, Level 4, Box 232, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QR, U.K., and ‡The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, U.K.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1996
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.135.5.1261